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Last Updated: Sep 02, 2025

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USMLE USMLE Exam Syllabus Topics:

TopicDetails
Topic 1
  • Cranial and peripheral nerve disorders
  • Cellular basis of the immune response and immunologic mediators
Topic 2
  • Infectious and inflammatory disorders of the eye
  • Adverse effects of drugs on the immune system
Topic 3
  • Deficiency primarily of humoral immunity
  • Immunologic and inflammatory disorders
Topic 4
  • Biology of tissue response to disease
  • Disorders of balance and spatial orientation
Topic 5
  • Eating disorders and impulse control disorders
  • Pharmacodynamic and pharmacokinetic processes
Topic 6
  • Adverse effects of drugs on the hematologic and lymphoreticular systems
  • Disorders associated with immunodeficiency
Topic 7
  • Adaptive behavioral responses to stress and illness
  • Biochemistry and molecular biology
Topic 8
  • Maladaptive behavioral responses to stress and illness
  • Immunologic and inflammatory disorders

Reference: http://www.usmle.org/step-1/#question-formats

USMLE United States Medical Licensing Examination

USMLE stands for United States Medical Licensing Examination. This is a series of medical exams coming in a few stages that all new doctors need to pass (starting from their time in med school) to be able to practice medicine.

USMLE Step 1 is a one-day (8 hours) examination. It includes 322 multiple-choice questions divided into 7 blocks of 46 items (60 minutes are given for completion of each block).

Step 1 of the USMLE (United States Medical Licensing Examination) is the first part of the United States Medical Licensing Examination. It is open to medical school student and graduates to assess their ability to apply important concepts fundamental to the practice of medicine. While American medical students usually take USMLE Step 1 at the end of the second year of medical school, all graduates of foreign medical schools must take this exam is they intend to practice medicine in the United States.

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